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Article

Mechanism of Nef-induced CD4 endocytosis: Nef connects CD4 with the mu chain of adaptor complexes.

The EMBO journal - 1 May 1998

Piguet V, Chen Y L, Mangasarian A, Foti M, Carpentier J L, Trono D

Abstract excerpt

The Nef protein of primate lentiviruses down-regulates the cell surface expression of CD4 and probably MHC I by connecting these receptors with the endocytic machinery. Here, we reveal that Nef interacts with the mu chains of adaptor complexes, key components of clathrin-coated pits. For human immunodeficiency virus type 2 (HIV-2) and simian immunodeficiency virus (SIV) Nef, this interaction occurs via...

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Identifiers

PMID: 9564030
DOI: 10.1093/emboj/17.9.2472
PMCID: PMC1170589

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