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Article

Human immunodeficiency virus Nef induces rapid internalization of the T-cell coreceptor CD8alphabeta.

Journal of virology - 1 Sept 2005

Stove Veronique, Van de Walle Inge, Naessens Evelien, Coene Elisabeth, Stove Christophe, Plum Jean, Verhasselt Bruno

Abstract excerpt

Human immunodeficiency virus (HIV) Nef is a membrane-associated protein decreasing surface expression of CD4, CD28, and major histocompatibility complex class I on infected cells. We report that Nef strongly down-modulates surface expression of the beta-chain of the CD8alphabeta receptor by accelerated endocytosis, while CD8 alpha-chain expression is less affected. By mutational analysis of the cytoplasmic tail...

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Share to Aspartic Acid Endopeptidases
Share to CD8 Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Down-Regulation

Share to Leukocytes, Mononuclear

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Source

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Identifiers

PMID: 16103193
DOI: 10.1128/JVI.79.17.11422-11433.2005
PMCID: PMC1193625

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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