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Article

Identification of a novel binding site between HIV type 1 Nef C-terminal flexible loop and AP2 required for Nef-mediated CD4 downregulation.

AIDS research and human retroviruses - 1 Apr 2013

Jin Yong-Jiu, Cai Catherine Yi, Mezei Mihaly, Ohlmeyer Michael, Sanchez Roberto, Burakoff Steven J

Abstract excerpt

HIV-1 Nef is an accessory protein necessary for HIV-1 virulence and rapid AIDS development. Nef promotes viral replication and infection by connecting CD4 and several other cell surface receptors to the clathrin adaptor protein AP2, resulting in the internalization and degradation of the receptors interacting with Nef. We investigated how Nef can mediate constitutive receptor endocytosis through the interaction...

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Source

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Identifiers

PMID: 23151229
DOI: 10.1089/AID.2012.0286
PMCID: PMC3903168

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Identification of a novel binding site between HIV type 1 Nef C-terminal flexible loop and AP2 required for Nef-mediated CD4 downregulation.PMID 23151229Read ↗

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