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Article

Endocytic sorting motif interactions involved in Nef-mediated downmodulation of CD4 and CD3.

Nature communications - 5 Sept 2017

Manrique Santiago, Sauter Daniel, Horenkamp Florian A, Lülf Sebastian, Yu Hangxing, Hotter Dominik, Anand Kanchan, Kirchhoff Frank, Geyer Matthias

Abstract excerpt

Lentiviral Nefs recruit assembly polypeptide complexes and target sorting motifs in cellular receptors to induce their internalization. While Nef-mediated CD4 downmodulation is conserved, the ability to internalize CD3 was lost in HIV-1 and its precursors. Although both functions play key roles in lentiviral replication and pathogenicity, the underlying structural requirements are poorly defined. Here, we...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28874665
DOI: 10.1038/s41467-017-00481-z
PMCID: PMC5585231

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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