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Article

Human Immunodeficiency Virus Type 1 Nef: Adapting to Intracellular Trafficking Pathways

1 Jun 2006

Abstract excerpt

The Nef protein of primate lentiviruses is a unique protein that has evolved in several ways to manipulate the biology of an infected cell to support viral replication, immune evasion, pathogenesis, and viral spread. Nef is a small (25- to 34-kDa), myristoylated protein that binds to a collection of cellular factors and acts as an adaptor to generate novel protein interactions to accomplish specific functions. Of...

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Identifiers

PMID: 16760313
DOI: 10.1128/mmbr.00042-05

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