Article

Molecular and mechanistic analysis of HIV Nef

2004-01-01

Abstract excerpt

The <i>nef</i> gene of HIV is required for complete viral pathogenicity. As an accessory gene with no known paradigm its principle function has been enigmatic. Nef is capable of a variety of in vitro effects including CD4 downregulation, MHC I down regulation, alteration of T cell signalling activity and enhancement of viral infectivity. The effect of Nef on host CD4 T cell signalling paths is intriguing as it is...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c371c51d-9322-541a-ac1c-e34cdfd2b1c7
DOI: 10.21954/ou.ro.0001019f

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Molecular and mechanistic analysis of HIV NefDOI 10.21954/ou.ro.0001019fRead

Nef-Mediated Suppression of T Cell Activation Was Lost in a Lentiviral Lineage that Gave Rise to HIV-1Semantic proximity Read

The Nef protein of primate lentivirusesSemantic proximity Read

Proteomic profiling of SupT1 cells reveal modulation of host proteins by HIV-1 Nef variants.Semantic proximity Read

How HIV Nef Proteins Hijack Membrane Traffic To Promote InfectionSemantic proximity Read

Towards a consensus for a role of Nef in both viral replication and immunomodulation?Semantic proximity Read

Molecular and Genetic Characterization of Natural Variants of HIV-1 Nef Gene from North India and its Functional Implication in Down-Regulation of MHC-I and CD-4.Semantic proximity Read

Structure–function relationships in HIV‐1 NefSemantic proximity Read

Emerging Role of Nef in the Development of HIV Associated Neurological DisordersSemantic proximity Read

Infectivity Enhancement by HIV-1 Nef Is Dependent on the Pathway of Virus Entry: Implications for HIV-Based Gene Transfer SystemsSemantic proximity Read

HIV ‐1 Nef: Taking Control of Protein TraffickingSemantic proximity Read

The paradox of HIV nef function: resolution of the contradictions.Semantic proximity Read

HIV-1 Nef CAWLEAQ motif: a regulator of monocytes invasion through ENO1 modulation.Semantic proximity Read