Article
Signaling but not trafficking function of HIV-1 protein Nef is essential for Nef-induced defects in human intrathymic T-cell development.
Blood - 15 Oct 2003
Stove Veronique, Naessens Evelien, Stove Christophe, Swigut Tomek, Plum Jean, Verhasselt Bruno
Abstract excerpt
The HIV-1 gene nef is important for progression toward AIDS and cellular depletion of the infected thymus. Expression of the Nef protein alone impairs human thymopoiesis. Here, we performed a structure-function analysis of the Nef protein by comparing the effect on T-cell development of different nef alleles, either wild type or defective for selected functions, expressed by human thymocytes. We show that...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.