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How HIV Nef Proteins Hijack Membrane Traffic To Promote Infection

30 Sept 2019

Abstract excerpt

The accessory protein Nef of human immunodeficiency virus (HIV) is a primary determinant of viral pathogenesis. Nef is abundantly expressed during infection and reroutes a variety of cell surface proteins to disrupt host immunity and promote the viral replication cycle. Nef counteracts host defenses by sequestering and/or degrading its targets via the endocytic and secretory pathways. Nef does this by physically...

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PMID: 31578291
DOI: 10.1128/jvi.01322-19

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