Article
Distinct Roles of Brd2 and Brd4 in Potentiating the Transcriptional Program for Th17 Cell Differentiation.
Molecular cell - 16 Mar 2017
Cheung Ka Lung, Zhang Fan, Jaganathan Anbalagan, Sharma Rajal, Zhang Qiang, Konuma Tsuyoshi, Shen Tong, Lee June-Yong, Ren Chunyan, Chen Chih-Hung, Lu Geming, Olson Matthew R, Zhang Weijia, Kaplan Mark H, Littman Dan R, Walsh Martin J, Xiong Huabao, Zeng Lei, Zhou Ming-Ming
Abstract excerpt
The BET proteins are major transcriptional regulators and have emerged as new drug targets, but their functional distinction has remained elusive. In this study, we report that the BET family members Brd2 and Brd4 exert distinct genomic functions at genes whose transcription they co-regulate during mouse T helper 17 (Th17) cell differentiation. Brd2 is associated with the chromatin insulator CTCF and the cohesin...
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