Article
The Bromodomain and Extra-Terminal Domain (BET) Family: Functional Anatomy of BET Paralogous Proteins
2016-10-24
Abstract excerpt
The BET family of proteins is characterized by the presence of two tandem bromodomains and an extra-terminal domain. The mammalian BET family of proteins comprises Brd2, Brd3, Brd4, and Brdt, which are encoded by paralogous genes that may have been generated by repeated duplication of an ancestral gene during evolution. Bromodomains that can specifically bind acetylated lysine residues in histones serve as chromat...
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Identifiers and source
- Literature Corpus work
- e4de5e91-d639-59bd-8af5-5404eb21f991
- DOI
- 10.20944/preprints201610.0100.v1