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The BET family in immunity and disease

18 Jan 2021

Abstract excerpt

Innate immunity serves as the rapid and first-line defense against invading pathogens, and this process can be regulated at various levels, including epigenetic mechanisms. The bromodomain and extraterminal domain (BET) family of proteins consists of four conserved mammalian members (BRD2, BRD3, BRD4, and BRDT) that regulate the expression of many immunity-associated genes and pathways. In particular, in response...

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PMID: 33462181
DOI: 10.1038/s41392-020-00384-4

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