Article

Ketamine induces synaptic and monoaminergic remodeling in human iPSC-derived neurons

2026-03-24

Abstract excerpt

<title>Abstract</title> <p> Major depressive disorder (MDD) is a leading cause of global disability, and a substantial proportion of patients develop treatment-resistant depression (TRD), highlighting the urgent need for mechanistically novel and fast-acting antidepressants. Ketamine has emerged as a paradigm-shifting therapy due to its rapid and robust antidepressant effects, yet its molecular mechanisms in hum...

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Literature Corpus work: 84b8717b-1f24-519d-8e28-24cdfab609a2
DOI: 10.21203/rs.3.rs-9096293/v1

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