Article
The ability of BDNF to modify neurogenesis and depressive-like behaviors is dependent upon phosphorylation of tyrosine residues 365/367 in the GABA(A)-receptor γ2 subunit.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 25 Sept 2013
Vithlani Mansi, Hines Rochelle M, Zhong Ping, Terunuma Miho, Hines Dustin J, Revilla-Sanchez Raquel, Jurd Rachel, Haydon Phillip, Rios Maribel, Brandon Nicholas, Yan Zhen, Moss Stephen J
Abstract excerpt
Brain-derived neurotrophic factor (BDNF) is a potent regulator of neuronal activity, neurogenesis, and depressive-like behaviors; however, downstream effectors by which BDNF exerts these varying actions remain to be determined. Here we reveal that BDNF induces long-lasting enhancements in the efficacy of synaptic inhibition by stabilizing γ2 subunit-containing GABA(A) receptors (GABA(A)Rs) at the cell surface,...
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