Article

Kappa opioid receptor activation induces epigenetic silencing of brain-derived neurotropic factor via HDAC5 in depression

2023-09-18

Abstract excerpt

Treatment-resistant depression (TRD) occurs in almost 50% of depressed patients. Central kappa opioid receptor (KOR) agonism has been demonstrated to induce depression and anxiety, while KOR antagonism alleviate depression like symptoms in rodent models and TRD in clinical studies. Previously, we have shown that sustained KOR activation leads to TRD-like phenotype in mice, and modulation of brain-derived neurotrop...

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Literature Corpus work: 4c94c7e1-0109-520b-99f1-7e0d4c9fb9e8
DOI: 10.1101/2023.09.18.558045

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