Article

A histidine switch regulates pH-dependent filament formation by the caspase-9 CARD

2025-06-03

Abstract excerpt

The caspase activation and recruitment domain (CARD) mediates protein-protein interactions in apoptotic and inflammatory signaling pathways. In humans, more than 30 proteins contain a CARD, several of which have been reported to polymerize into helical filaments. Here we found that the CARD from the apoptotic protease caspase-9 (C9 CARD ) self assembles into filaments in vitro at physiological pH and salt concen...

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Literature Corpus work: 477b4a46-04db-5c05-9b8d-6ebc895424dc
DOI: 10.1101/2025.06.02.657148

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