Article
Structural basis for distinct inflammasome complex assembly by human NLRP1 and CARD8.
Nature communications - 8 Jan 2021
Gong Qin, Robinson Kim, Xu Chenrui, Huynh Phuong Thao, Chong Kelvin Han Chung, Tan Eddie Yong Jun, Zhang Jiawen, Boo Zhao Zhi, Teo Daniel Eng Thiam, Lay Kenneth, Zhang Yaming, Lim John Soon Yew, Goh Wah Ing, Wright Graham, Zhong Franklin L, Reversade Bruno, Wu Bin
Abstract excerpt
Nod-like receptor (NLR) proteins activate pyroptotic cell death and IL-1 driven inflammation by assembling and activating the inflammasome complex. Closely related sensor proteins NLRP1 and CARD8 undergo unique auto-proteolysis-dependent activation and are implicated in auto-inflammatory diseases; however, their mechanisms of activation are not understood. Here we report the structural basis of how the activating...
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