Article

Structural mechanism of CARD8 regulation by DPP9

2021-01-14

Abstract excerpt

<h4>SUMMARY</h4> CARD8 is a germline-encoded pattern recognition receptor that detects intracellular danger signals. Like the related inflammasome sensor NLRP1, CARD8 undergoes constitutive autoprocessing within its function-to-find domain (FIIND), generating two polypeptides that stay associated and autoinhibited. Certain pathogen- and danger-associated activities, including the inhibition of the serine dipeptid...

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Literature Corpus work: 98a999ef-c091-5c36-b210-755841c07902
DOI: 10.1101/2021.01.13.426575

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