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Article

Distinct axial and lateral interactions within homologous filaments dictate the signaling specificity and order of the AIM2-ASC inflammasome.

Nature communications - 12 May 2021

Matyszewski Mariusz, Zheng Weili, Lueck Jacob, Mazanek Zachary, Mohideen Naveen, Lau Albert Y, Egelman Edward H, Sohn Jungsan

Abstract excerpt

Inflammasomes are filamentous signaling platforms integral to innate immunity. Currently, little is known about how these structurally similar filaments recognize and distinguish one another. A cryo-EM structure of the AIM2PYD filament reveals that the architecture of the upstream filament is essentially identical to that of the adaptor ASCPYD filament. In silico simulations using Rosetta and molecular dynamics...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33980849
DOI: 10.1038/s41467-021-23045-8
PMCID: PMC8115694

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