Article

Structure-based alignment of human caspase recruitment domains provides a framework for understanding their function

2016-11-15

Abstract excerpt

Intracellular signalling is driven by protein-protein interactions. Members of the Death Domain superfamily mediate protein-protein interactions in both cell death and innate immune signalling pathways. They drive the formation of macromolecular complexes that act as a scaffold for protein recruitment and downstream signal transduction. Death Domain family members have low sequence identity, complicating their ide...

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Literature Corpus work: d42eb82a-6514-5b9b-b8eb-7c319f7541e8
DOI: 10.1101/087908

Open publication

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