Article
Structural basis of dynamic P5CS filaments.
eLife - 14 Mar 2022
Zhong Jiale, Guo Chen-Jun, Zhou Xian, Chang Chia-Chun, Yin Boqi, Zhang Tianyi, Hu Huan-Huan, Lu Guang-Ming, Liu Ji-Long
Abstract excerpt
The bifunctional enzyme Δ1-pyrroline-5-carboxylate synthase (P5CS) is vital to the synthesis of proline and ornithine, playing an essential role in human health and agriculture. Pathogenic mutations in the P5CS gene (ALDH18A1) lead to neurocutaneous syndrome and skin relaxation connective tissue disease in humans, and P5CS deficiency seriously damages the ability to resist adversity in plants. We have recently...
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