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Article

ASC filament formation serves as a signal amplification mechanism for inflammasomes.

Nature communications - 22 Jun 2016

Dick Mathias S, Sborgi Lorenzo, Rühl Sebastian, Hiller Sebastian, Broz Petr

Abstract excerpt

A hallmark of inflammasome activation is the ASC speck, a micrometre-sized structure formed by the inflammasome adaptor protein ASC (apoptosis-associated speck-like protein containing a CARD), which consists of a pyrin domain (PYD) and a caspase recruitment domain (CARD). Here we show that assembly of the ASC speck involves oligomerization of ASC(PYD) into filaments and cross-linking of these filaments by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27329339
DOI: 10.1038/ncomms11929
PMCID: PMC4917984

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