Article

Structural basis of dynamic P5CS filaments

2021-12-02

Abstract excerpt

The bifunctional enzyme Δ 1 -pyrroline-5-carboxylate synthase (P5CS) is central to the synthesis of proline and ornithine. Pathogenic mutations in P5CS gene (ALDH18A1) lead to neurocutaneous syndrome and skin relaxation connective tissue disease in humans, and P5CS deficiency seriously damages the ability to resist adversity in plants, which has an essential role in agriculture and human health. Recently, P5CS ha...

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Literature Corpus work: 2f0e782f-5ba4-5d86-82f7-674cac96d2e9
DOI: 10.1101/2021.12.02.470899

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