Article
Mechanistic insights into caspase-9 activation by the structure of the apoptosome holoenzyme.
Proceedings of the National Academy of Sciences of the United States of America - 14 Feb 2017
Li Yini, Zhou Mengying, Hu Qi, Bai Xiao-Chen, Huang Weiyun, Scheres Sjors H W, Shi Yigong
Abstract excerpt
Mammalian intrinsic apoptosis requires activation of the initiator caspase-9, which then cleaves and activates the effector caspases to execute cell killing. The heptameric Apaf-1 apoptosome is indispensable for caspase-9 activation by together forming a holoenzyme. The molecular mechanism of caspase-9 activation remains largely enigmatic. Here, we report the cryoelectron microscopy (cryo-EM) structure of an...
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