Article

Mutational impact and signature of ionizing radiation

2021-01-13

Abstract excerpt

Whole-genome sequencing (WGS) of human tumors and normal cells exposed to various carcinogens has revealed distinct mutational patterns that provide deep insights into the DNA damage and repair processes. Although ionizing radiation (IR) is conventionally known as a strong carcinogen, its genome-wide mutational impacts have not been comprehensively investigated at the single-nucleotide level. Here, we explored the...

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Literature Corpus work: 476dab88-dc0f-51c8-a621-d0c703ca5d15
DOI: 10.1101/2021.01.12.426324

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