Article
Identification of the mutation signature of the cancer genome caused by irradiation.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology - 1 Feb 2021
Kageyama Shun-Ichiro, Du Junyan, Kaneko Syuzo, Hamamoto Ryuji, Yamaguchi Shigeo, Yamashita Riu, Okumura Masayuki, Motegi Atsushi, Hojo Hidehiro, Nakamura Masaki, Tsuchihara Katsuya, Akimoto Tetsuo
Abstract excerpt
BACKGROUND AND PURPOSE: Ionising radiation causes mutations in the genomes of tumour cells and serves as a potent treatment for cancer. However, the mutation signatures in the cancer genome following ionising radiation have not been documented. MATERIALS AND METHODS: We established an in vitro experimental system to analyse the presence of de novo mutations in the cancer genome of irradiated (60 Gy/20 fr/4 weeks)...
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