Article

Mutagenic impact and evolutionary influence of radiotherapy in hematologic malignancies

2024-11-18

Abstract excerpt

<h4>ABSTRACT</h4> Ionizing radiotherapy (RT) is a widely used palliative and curative treatment strategy for malignancies. In solid tumors, RT-induced double strand breaks lead to the accumulation of indels, and their repair by non-homologous end-joining has been linked to the ID8 mutational signature in resistant cells. However, the extent of RT-induced DNA damage in hematologic malignancies and its impact on th...

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Literature Corpus work: 536c3511-79ed-5992-9427-78c880c1cdfd
DOI: 10.1101/2024.11.15.623836

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