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Replication-stress-associated DSBs induced by ionizing radiation risk genomic destabilization and associated clonal evolution

18 Mar 2021

Abstract excerpt

Exposure to ionizing radiation is associated with cancer risk. Although multiple types of DNA damage are caused by radiation, it remains unknown how this damage is associated with cancer risk. Here, we show that after repair of double-strand breaks (DSBs) directly caused by radiation (dir-DSBs), irradiated cells enter a state at higher risk of genomic destabilization due to accumulation of...

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PMID: 33870130
DOI: 10.1016/j.isci.2021.102313

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