Article
Mutational signatures of ionizing radiation in second malignancies.
Nature communications - 12 Sept 2016
Behjati Sam, Gundem Gunes, Wedge David C, Roberts Nicola D, Tarpey Patrick S, Cooke Susanna L, Van Loo Peter, Alexandrov Ludmil B, Ramakrishna Manasa, Davies Helen, Nik-Zainal Serena, Hardy Claire, Latimer Calli, Raine Keiran M, Stebbings Lucy, Menzies Andy, Jones David, Shepherd Rebecca, Butler Adam P, Teague Jon W, Jorgensen Mette, Khatri Bhavisha, Pillay Nischalan, Shlien Adam, Futreal P Andrew, Badie Christophe, McDermott Ultan, Bova G Steven, Richardson Andrea L, Flanagan Adrienne M, Stratton Michael R, Campbell Peter J
Abstract excerpt
Ionizing radiation is a potent carcinogen, inducing cancer through DNA damage. The signatures of mutations arising in human tissues following in vivo exposure to ionizing radiation have not been documented. Here, we searched for signatures of ionizing radiation in 12 radiation-associated second malignancies of different tumour types. Two signatures of somatic mutation characterize ionizing radiation exposure...
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