Quantitative and qualitative mutational impact of ionizing radiation on normal cells.

doi:10.1016/j.xgen.2024.100499

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Article

Quantitative and qualitative mutational impact of ionizing radiation on normal cells.

Cell genomics - 14 Feb 2024

Youk Jeonghwan, Kwon Hyun Woo, Lim Joonoh, Kim Eunji, Kim Taewoo, Kim Ryul, Park Seongyeol, Yi Kijong, Nam Chang Hyun, Jeon Sara, An Yohan, Choi Jinwook, Na Hyelin, Lee Eon-Seok, Cho Youngwon, Min Dong-Wook, Kim HyoJin, Kang Yeong-Rok, Choi Si Ho, Bae Min Ji, Lee Chang Geun, Kim Joon-Goon, Kim Young Seo, Yu Tosol, Lee Won-Chul, Shin Jong-Yeon, Lee Dong Soo, Kim Tae-You, Ku Taeyun, Kim Su Yeon, Lee Joo-Hyeon, Koo Bon-Kyoung, Lee Hyunsook, Yi On Vox, Han Eon Chul, Chang Ji Hyun, Kim Kyung Su, Son Tae Gen, Ju Young Seok

Abstract excerpt

The comprehensive genomic impact of ionizing radiation (IR), a carcinogen, on healthy somatic cells remains unclear. Using large-scale whole-genome sequencing (WGS) of clones expanded from irradiated murine and human single cells, we revealed that IR induces a characteristic spectrum of short insertions or deletions (indels) and structural variations (SVs), including balanced inversions, translocations, composite...

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Identifiers

PMID: 38359788
DOI: 10.1016/j.xgen.2024.100499
PMCID: PMC10879144

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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