T-cell receptor structures and predictive models reveal comparable alpha and beta chain structural diversity despite differing genetic complexity.

Abstract excerpt

T-cell receptor (TCR) structures are currently under-utilised in early-stage drug discovery and repertoire-scale informatics. Here, we leverage a large dataset of solved TCR structures from Immunocore to evaluate the current state-of-the-art for TCR structure prediction, and identify which regions of the TCR remain challenging to model. Through clustering analyses and the training of a TCR-specific model capable...

Topics

• Receptors, Antigen, T-Cell, alpha-beta
• Humans
• Models, Molecular
• Genetic Variation
• Receptors, Antigen, T-Cell