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Article

Cryo-Electron Tomography Reveals Nanoscale Thick Filament Disorganization in MYH7 P710R Hypertrophic Cardiomyopathy Cardiomyocytes.

ACS nano - 1 Sept 2026

Zaoralová Magda, Yoniles Joseph, Giri Prerna, Held Richard G, Vander Roest Alison, Dahlberg Peter D, Bernstein Daniel, Dunn Alexander R, Engel Leeya

Abstract excerpt

Hypertrophic cardiomyopathy (HCM) is the most common monogenic inherited heart disease and is a major cause of sudden death in individuals under 35 years of age. HCM is associated with progressive tissue-level disarray and subcellular disorganization in individual cardiomyocytes. Mutations in β-cardiac myosin (MYH7), the second most common genetic cause of HCM, commonly result in changes in sarcomeric force...

Read the complete abstract on PubMed

Topics

Humans
Myocytes, Cardiac
Cardiomyopathy, Hypertrophic
Electron Microscope Tomography
Myosin Heavy Chains

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Cardiac Myosins

Cryoelectron Microscopy

Sarcomeres

Induced Pluripotent Stem Cells

Mutation

Source

Identifiers

PMID: 42689701
DOI: 10.1021/acsnano.6c03369

Genes

MYH7

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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