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Article

High-Resolution Cryo-EM Structure of the Cardiac Actomyosin Complex.

Structure (London, England : 1993) - 7 Jan 2021

Risi Cristina, Schäfer Luisa U, Belknap Betty, Pepper Ian, White Howard D, Schröder Gunnar F, Galkin Vitold E

Abstract excerpt

Heart contraction depends on a complicated array of interactions between sarcomeric proteins required to convert chemical energy into mechanical force. Cyclic interactions between actin and myosin molecules, controlled by troponin and tropomyosin, generate the sliding force between the actin-based thin and myosin-based thick filaments. Alterations in this sophisticated system due to missense mutations can lead to...

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Identifiers

PMID: 33065066
DOI: 10.1016/j.str.2020.09.013
PMCID: PMC7796959

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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