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Article

Sorting of a nonmuscle tropomyosin to a novel cytoskeletal compartment in skeletal muscle results in muscular dystrophy.

The Journal of cell biology - 30 Aug 2004

Kee Anthony J, Schevzov Galina, Nair-Shalliker Visalini, Robinson C Stephen, Vrhovski Bernadette, Ghoddusi Majid, Qiu Min Ru, Lin Jim J-C, Weinberger Ron, Gunning Peter W, Hardeman Edna C

Abstract excerpt

Tropomyosin (Tm) is a key component of the actin cytoskeleton and >40 isoforms have been described in mammals. In addition to the isoforms in the sarcomere, we now report the existence of two nonsarcomeric (NS) isoforms in skeletal muscle. These isoforms are excluded from the thin filament of the sarcomere and are localized to a novel Z-line adjacent structure. Immunostained cross sections indicate that one Tm...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15337777
DOI: 10.1083/jcb.200406181
PMCID: PMC2172434

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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