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Noncanonical imprinting: intergenerational epigenetic inheritance mediated by Polycomb complexes

26 Dec 2022

Abstract excerpt

Genomic imprinting is illustrative of intergenerational epigenetic inheritance. The passage of parental genomes into the embryo is accompanied by epigenetic modifications, resulting in imprinted monoallelic gene expression in mammals. Some imprinted genes are regulated by maternal inheritance of H3K27me3, which is termed noncanonical imprinting. Noncanonical imprinting is established by Polycomb repressive...

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PMID: 36577293
DOI: 10.1016/j.gde.2022.102015

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