Article

Adaptation of a transmitted/founder simian-human immunodeficiency virus for enhanced replication in rhesus macaques

2022-12-12

Abstract excerpt

Transmitted/founder (TF) simian-human immunodeficiency viruses (SHIVs) express HIV-1 envelopes modified at position 375 to efficiently infect rhesus macaques while preserving authentic HIV-1 Env biology. TF SHIV.C.CH505 is an extensively characterized virus shown to recapitulate key features of HIV-1 immunobiology, including CCR5-tropism, a tier 2 neutralization profile, reproducible early viral kinetics, and auth...

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Literature Corpus work: 47486bc0-676d-5b5a-98bf-17467883f0b6
DOI: 10.1101/2022.12.12.520031

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