Article
Derivation and Characterization of Pathogenic Transmitted/Founder Molecular Clones from Simian Immunodeficiency Virus SIVsmE660 and SIVmac251 following Mucosal Infection.
Journal of virology - 1 Oct 2016
Lopker Michael J, Del Prete Gregory Q, Estes Jacob D, Li Hui, Reid Carolyn, Newman Laura, Lipkey Leslie, Camus Celine, Easlick Juliet L, Wang Shuyi, Decker Julie M, Bar Katharine J, Learn Gerald, Pal Ranajit, Weiss Deborah E, Hahn Beatrice H, Lifson Jeffrey D, Shaw George M, Keele Brandon F
Abstract excerpt
UNLABELLED: Currently available simian immunodeficiency virus (SIV) infectious molecular clones (IMCs) and isolates used in nonhuman primate (NHP) models of AIDS were originally derived from infected macaques during chronic infection or end stage disease and may not authentically recapitulate features of transmitted/founder (T/F) genomes that are of particular interest in transmission, pathogenesis, prevention,...
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