Rational design and in vivo selection of SHIVs encoding transmitted/founder subtype C HIV-1 envelopes.

doi:10.1371/journal.ppat.1007632

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Article

Rational design and in vivo selection of SHIVs encoding transmitted/founder subtype C HIV-1 envelopes.

PLoS pathogens - 1 Apr 2019

O'Brien Sean P, Swanstrom Adrienne E, Pegu Amarendra, Ko Sung-Youl, Immonen Taina T, Del Prete Gregory Q, Fennessey Christine M, Gorman Jason, Foulds Kathryn E, Schmidt Stephen D, Doria-Rose Nicole, Williamson Carolyn, Hatziioannou Theodora, Bieniasz Paul D, Li Hui, Shaw George M, Mascola John R, Koup Richard A, Kwong Peter D, Lifson Jeffrey D, Roederer Mario, Keele Brandon F

Abstract excerpt

Chimeric Simian-Human Immunodeficiency Viruses (SHIVs) are an important tool for evaluating anti-HIV Env interventions in nonhuman primate (NHP) models. However, most unadapted SHIVs do not replicate well in vivo limiting their utility. Furthermore, adaptation in vivo often negatively impacts fundamental properties of the Env, including neutralization profiles. Transmitted/founder (T/F) viruses are particularly...

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PMID: 30943274
DOI: 10.1371/journal.ppat.1007632
PMCID: PMC6447185

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