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Article

Infection of rhesus macaques with a pool of simian immunodeficiency virus with the envelope genes from acute HIV-1 infections.

AIDS research and therapy - 25 Nov 2016

Krebs Kendall C, Tian Meijuan, Asmal Mohammed, Ling Binhua, Nelson Kenneth, Henry Kenneth, Gibson Richard, Li Yuejin, Han Weining, Shattock Robin J, Veazey Ronald S, Letvin Norman, Arts Eric J, Gao Yong

Abstract excerpt

BACKGROUND: New simian-human immunodeficiency chimeric viruses with an HIV-1 env (SHIVenv) are critical for studies on HIV pathogenesis, vaccine development, and microbicide testing. Macaques are typically exposed to single CCR5-using SHIVenv which in most instances does not reflect the conditions during acute/early HIV infection (AHI) in humans. Instead of individual and serial testing new SHIV constructs, a...

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Identifiers

PMID: 27906032
DOI: 10.1186/s12981-016-0125-8
PMCID: PMC5124249

Genes

CCR5

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