Infection of monkeys by simian-human immunodeficiency viruses with transmitted/founder clade C HIV-1 envelopes.

doi:10.1016/j.virol.2014.10.032

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Article

Infection of monkeys by simian-human immunodeficiency viruses with transmitted/founder clade C HIV-1 envelopes.

Virology - 15 Jan 2015

Asmal Mohammed, Luedemann Corinne, Lavine Christy L, Mach Linh V, Balachandran Harikrishnan, Brinkley Christie, Denny Thomas N, Lewis Mark G, Anderson Hanne, Pal Ranajit, Sok Devin, Le Khoa, Pauthner Matthias, Hahn Beatrice H, Shaw George M, Seaman Michael S, Letvin Norman L, Burton Dennis R, Sodroski Joseph G, Haynes Barton F, Santra Sampa

Abstract excerpt

Simian-human immunodeficiency viruses (SHIVs) that mirror natural transmitted/founder (T/F) viruses in man are needed for evaluation of HIV-1 vaccine candidates in nonhuman primates. Currently available SHIVs contain HIV-1 env genes from chronically-infected individuals and do not reflect the characteristics of biologically relevant HIV-1 strains that mediate human transmission. We chose to develop clade C SHIVs,...

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Identifiers

PMID: 25462344
DOI: 10.1016/j.virol.2014.10.032
PMCID: PMC4280322

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