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Article

In vivo adaptation of SHIV<sub>SF162</sub>: Chimeric virus expressing a NSI, CCR5‐specific envelope protein

10 Aug 1999

Abstract excerpt

The chemokine receptor CCR5 is known to be a critical determinant of human immunodeficiency virus (HIV) transmission and pathogenesis in the human host. Towards the development of a macaque model to evaluate the efficacy of vaccines and therapeutics against infection with CCR5-specific viruses, and to delineate the pathogenic properties of such viruses, we constructed a chimeric simian human immunodeficiency...

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PMID: 10593481
DOI: 10.1111/j.1600-0684.1999.tb00265.x

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