Article

Identification of HIV-1 Envelope Mutations that Enhance Entry Using Macaque CD4 and CCR5

2019-12-03

Abstract excerpt

Although Rhesus macaques are an important animal model for HIV-1 vaccine development research, most transmitted HIV-1 strains replicate poorly in macaque cells. A major genetic determinant of this species-specific restriction is a non-synonymous mutation in macaque CD4 that results in reduced HIV-1 Envelope (Env)-mediated viral entry compared to human CD4. Recent research efforts employing either laboratory evolut...

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Literature Corpus work: e3f3b1eb-0b84-5dee-ae93-2deaa811d17f
DOI: 10.1101/863043

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