Article

Conformation of HIV-1 Envelope governs rhesus CD4 usage and simian-human immunodeficiency virus replication

2021-08-25

Abstract excerpt

Infection of rhesus macaques with simian-human immunodeficiency viruses (SHIVs) is the preferred model system for vaccine development because SHIVs encode HIV-1 envelope glycoproteins (Env) – a key target of HIV-1 neutralizing antibodies. Since the goal of vaccines is to prevent new infections, SHIVs encoding circulating HIV-1 Env are desired as challenge viruses. Development of such biologically relevant SHIVs ha...

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Literature Corpus work: 1b9be617-889e-52d8-8e20-0e572ddb2587
DOI: 10.1101/2021.08.25.457697

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