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Article

Differential Outcomes following Optimization of Simian-Human Immunodeficiency Viruses from Clades AE, B, and C.

Journal of virology - 4 May 2020

Tartaglia Lawrence J, Gupte Siddhant, Pastores Kevin C, Trott Sebastien, Abbink Peter, Mercado Noe B, Li Zhenfeng, Liu Po-Ting, Borducchi Erica N, Chandrashekar Abishek, Bondzie Esther Apraku, Hamza Venous, Kordana Nicole, Mahrokhian Shant, Lavine Christy L, Seaman Michael S, Li Hui, Shaw George M, Barouch Dan H

Abstract excerpt

Simian-human immunodeficiency virus (SHIV) infection of rhesus monkeys is an important preclinical model for human immunodeficiency virus type 1 (HIV-1) vaccines, therapeutics, and cure strategies. SHIVs have been optimized by incorporating HIV-1 Env residue 375 mutations that mimic the bulky or hydrophobic residues typically found in simian immunodeficiency virus (SIV) Env to improve rhesus CD4 binding. We...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 32132241
DOI: 10.1128/JVI.01860-19
PMCID: PMC7199416

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Differential Outcomes following Optimization of Simian-Human Immunodeficiency Viruses from Clades AE, B, and C.PMID 32132241Read ↗

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