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Article

Adaptation of subtype a human immunodeficiency virus type 1 envelope to pig-tailed macaque cells.

Journal of virology - 1 May 2011

Humes Daryl, Overbaugh Julie

Abstract excerpt

The relevance of simian/human immunodeficiency virus (SHIV) infection of macaques to HIV-1 infection in humans depends on how closely SHIVs mimic HIV-1 transmission, pathogenesis, and diversity. Circulating HIV-1 strains are predominantly subtypes C and A and overwhelmingly require CCR5 for entry, yet most SHIVs incorporate CXCR4-using subtype B envelopes (Envs). While pathogenic subtype C-based SHIVs have been...

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Share to Adaptation, Biological
Share to Amino Acid Substitution
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Macaca nemestrina

Share to Recombination, Genetic

Share to Simian Immunodeficiency Virus

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Source

Open in PubMed Open full text

Identifiers

PMID: 21325401
DOI: 10.1128/JVI.02244-10
PMCID: PMC3126259

Genes

CCR5
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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