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New SHIVs and Improved Design Strategy for Modeling HIV-1 Transmission, Immunopathogenesis, Prevention and Cure

2021-01-13

Abstract excerpt

Simian-human immunodeficiency virus (SHIV) chimeras contain the HIV-1 envelope ( env ) gene embedded within an SIVmac proviral backbone. Previously, we showed that substitution of Env residue 375-Ser by bulky aromatic residues enhances Env binding to rhesus CD4 and enables primary or transmitted/founder (T/F) HIV-1 Envs to support efficient SHIV replication in rhesus macaques (RMs). Here, we test this design stra...

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Identifiers and source

Literature Corpus work
917b2436-76bf-55bd-a7de-a24b2404528f
DOI
10.1101/2021.01.13.426578
Open publication

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New SHIVs and Improved Design Strategy for Modeling HIV-1 Transmission, Immunopathogenesis, Prevention and CureDOI 10.1101/2021.01.13.426578
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