Article

SORLA mediates endocytic uptake of proIAPP and protects against islet amyloid deposition

2022-04-21

Abstract excerpt

<h4>Aims/ hypothesis</h4> Sorting-related receptor with type A repeats (SORLA) is a neuronal sorting receptor that prevents accumulation of amyloid-beta peptides, the main constituent of senile plaques in Alzheimer disease. Recent transcriptomic studies show that SORLA transcripts are also found in pancreatic islet beta cells, yet the role of SORLA in islets is unclear so far. Based on its protective role in redu...

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Literature Corpus work: 473aa553-6bb7-5864-a88d-490b1679b2f8
DOI: 10.1101/2022.04.21.488729

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