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The Alzheimer’s-Associated <i>SORL1</i> p.Y1816C Variant Impairs APP Sorting, Axonal Trafficking, and Neuronal Activity in iPSC-Derived Brain Models

2025-07-30

Abstract excerpt

<h4>Background</h4> SORL1 , encoding the sorting receptor SORLA, is now recognized as the fourth autosomal dominant Alzheimer’s disease (AD) gene. Loss of SORLA function is known to disrupt endosomal trafficking and enhance amyloidogenic APP processing, two key aspects of the onset and progression of AD. However, the pathogenic consequences of disrupted endolysosomal pathways, deregulated protein sorting, as well...

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Literature Corpus work
78144321-0fc6-576c-b547-9a8f9791019d
DOI
10.1101/2025.07.28.667160
Open publication

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The Alzheimer’s-Associated <i>SORL1</i> p.Y1816C Variant Impairs APP Sorting, Axonal Trafficking, and Neuronal Activity in iPSC-Derived Brain ModelsDOI 10.1101/2025.07.28.667160
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