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Article

SORLA facilitates insulin receptor signaling in adipocytes and exacerbates obesity.

The Journal of clinical investigation - 1 Jul 2016

Schmidt Vanessa, Schulz Nadja, Yan Xin, Schürmann Annette, Kempa Stefan, Kern Matthias, Blüher Matthias, Poy Matthew N, Olivecrona Gunilla, Willnow Thomas E

Abstract excerpt

In humans, genetic variation of sortilin-related receptor, L(DLR class) A repeats containing (SORL1), which encodes the intracellular sorting receptor SORLA, is a major genetic risk factor for familial and sporadic forms of Alzheimer's disease. Recent GWAS analysis has also associated SORL1 with obesity in humans and in mouse models, suggesting that this receptor may play a role in regulating metabolism. Here,...

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Topics

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Share to Adipocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glucose

Share to Hydrolysis

Share to LDL-Receptor Related Proteins

Share to Receptor, Insulin

Share to Receptors, LDL

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Source

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Identifiers

PMID: 27322061
DOI: 10.1172/JCI84708
PMCID: PMC4922706

Genes

SORL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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SORLA facilitates insulin receptor signaling in adipocytes and exacerbates obesity.PMID 27322061Read ↗

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Diabetes-associated SorCS1 regulates Alzheimer's amyloid-beta metabolism: evidence for involvement of SorL1 and the retromer complex.Semantic proximity Read ↗

Soluble SorCS1 binds the insulin receptor to enhance insulin sensitivitySemantic proximity Read ↗

The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease.Semantic proximity Read ↗

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Sortilin-mediated translocation of mitochondrial ACSL1 impairs adipocyte thermogenesis and energy expenditure in male miceSemantic proximity Read ↗

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SORCS1 is necessary for normal insulin secretory granule biogenesis in metabolically stressed β cells.Semantic proximity Read ↗

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