Article

Endosomal trafficking is required for glycosylation and normal maturation of the Alzheimer’s-associated protein sorLA

2020-07-13

Abstract excerpt

<h4>ABSTRACT</h4> The sorting receptor sorLA encoded by the SORL1 gene is implicated in Alzheimer’s disease (AD) pathogenesis. Genetic studies have identified AD-associated SORL1 mutations and the expression of sorLA in AD brains is reported to be reduced. SorLA is a receptor of the retromer trafficking complex and functions at the endosome, and deficiency in sorLA phenocopies the endosomal pathologies found in...

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Literature Corpus work: 5d3b3b59-8c51-540f-b6d1-384daae8e20d
DOI: 10.1101/2020.07.12.199885

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