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Article

Risk factor SORL1: from genetic association to functional validation in Alzheimer's disease.

Acta neuropathologica - 1 Nov 2016

Andersen Olav M, Rudolph Ina-Maria, Willnow Thomas E

Abstract excerpt

Alzheimer's disease (AD) represents one of the most dramatic threats to healthy aging and devising effective treatments for this devastating condition remains a major challenge in biomedical research. Much has been learned about the molecular concepts that govern proteolytic processing of the amyloid precursor protein to amyloid-β peptides (Aβ), and how accelerated accumulation of neurotoxic Aβ peptides underlies...

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Source

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Identifiers

PMID: 27638701
DOI: 10.1007/s00401-016-1615-4
PMCID: PMC5073117

Genes

SORL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Risk factor SORL1: from genetic association to functional validation in Alzheimer's disease.PMID 27638701Read ↗

An alternative transcript of the Alzheimer's disease risk gene SORL1 encodes a truncated receptor.Semantic proximity Read ↗

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The SORL1 p.Y1816C variant causes impaired endosomal dimerization and autosomal dominant Alzheimer’s diseaseSemantic proximity Read ↗

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SORL1 variants across Alzheimer's disease European American cohorts.Semantic proximity Read ↗

Familial Alzheimer disease mutation identifies novel role of SORLA in release of neurotrophic exosomesSemantic proximity Read ↗

The<i>SORL1</i>p.Y1816C variant causes impaired endosomal dimerization and autosomal dominant Alzheimer’s diseaseSemantic proximity Read ↗

The neuronal sortilin-related receptor gene SORL1 and late-onset Alzheimer's disease.Semantic proximity Read ↗

The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease.Semantic proximity Read ↗

Lysosomal Sorting of Amyloid-β by the SORLA Receptor Is Impaired by a Familial Alzheimer’s Disease MutationSemantic proximity Read ↗

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